Edmund Andrews came to Carlisle with their father Solomon and brother Issachar from Ipswich on ox sleds during the frigid winter of 1765. The family purchased a three-hundred-acre tract of land near the Concord River where they cleared a small farm and built a homestead and fulling mill. In the 20th century, this historic farm would become the Greenough Conservation Land.
During the revolution, Edmund Andrews served as a member of Captain Abishai Brown’s company in Colonel Josiah Whitney’s regiment. After the war, he constructed a new house located near what is today Peter Hans Road. In 1784 he was appointed constable of Carlisle and he served as highway surveyor beginning in 1787, overseeing the creation of many well-traveled roads that still exist today.
Edmund Andrews is buried in Carlisle's Central Burying Ground.